http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1590449-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5d5bb9b9a6d998b72b154ceb1895a3f5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2035-124 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2035-122 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783 |
| filingDate | 2004-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_655d27bff6247db18c9a955c0ff67729 |
| publicationDate | 2005-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1590449-A2 |
| titleOfInvention | Icos+ suppresser t cells |
| abstract | Human antigen-presenting cells (APC), on which the costimulatory ligands CD40, CD80 and CD86 are blocked e.g. by antibodies, are unable to fully activate allogeneic T cells in vitro. Instead, they induce a long-lasting functional T cell alteration with lack of IL-2, IL-5 and IL-13 production upon allogeneic restimulation. Present invention demonstrates that despite costimulation blockade during in vitro allogeneic stimulation, a non-proliferating responder T cell subpopulation is activated to express ICOS. Removal of these ICOS-expressing cells restores the capacity of reciprocal ICOS negative cells to proliferate and to produce Th1 and Th2 cytokines after allogeneic restimulation. ICOS+ cells on the other hand are anergic at the level of proliferation and Th1 and Th2 cytokine production. However, these cells can produce IL-10, and they suppress the allogeneic responses of either primed or naive T cells through inhibition of IL-2 mRNA transcription. Suppression is not mediated by IL-10, but depends on cell-cell contact. Thus a subtype of regulatory T cells in human blood can be activated in the absence of costimulatory signals from CD40, CD80 and CD86, and that they can be identified by expression of ICOS after activation. |
| priorityDate | 2003-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 136.