http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1589977-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47d6dec86dd9ddfa566eb69ea70a372e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-593 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0014 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-593 |
| filingDate | 2004-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdfa8be98f0822d3750f42ad8b3902a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a3edb3eba5dcf339efe8dc557a11d12 |
| publicationDate | 2005-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1589977-A1 |
| titleOfInvention | Topical ointment for vesicating chemical warfare agents |
| abstract | The regulatory effects of the active form of vitamin D, 1-α, 25-dihydroxyvitamin D3(1-α, 25(OH)2D3) were assessed on the cytokine and chemokine secretion induced by sulfur mustard (HD) on human skin fibroblasts (HSF) and human epidermal keratinocytes (HEK). Stimulation of HSF with HD (10-4 M for 24 hours at 37° C) resulted in about a 5-fold increase in the secretion of interleukin-6 (IL-6) and over a 10- fold increase for interleukin-8 (IL-8), which was inhibited by 1-α, 25(OH)2D3, at ≤ 10-9 M. 1-α, 25(OH)2D3 also suppressed IL-8 secretion by five-fold and IL-6 by four-fold on HD-stimulated HEK at concentrations ≤ 10-9 M. The effect of 1-α, 25(OH)2D3 was dose-dependent for the suppression of IL-6 and IL-8 induced by HD on HSF/HEK, apparent at nanomolar concentrations. Results indicate that the suppression of these inflammatory mediators by 1-α, 25(OH)2D3 is dependent on the source of the primary cultures, cell densities, and kinetics of pretreatments. In addition, a composition for a topical ointment for wound healing in mammals exposed to vesicating chemical warfare agents is also disclosed. The composition includes a compound or the combination of a 1-α, 25(OH)2D3 and shark liver oil. The steroid hormone 1-α, 25(OH)2D3 (calcitriol), in addition to its crucial role in calcium homeostasis, provides benefits to the immune system by regulating cell proliferation, differentiation and maturation. These benefits are effectuated through the control of protooncogenes and the regulation of cytokine production. |
| priorityDate | 2003-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.