| abstract |
Process for the preparation of a composition comprising a biofunctionalnpolymer substrate and biofunctional material substrate adapted for use in or innassociation with the human or animal body, cultivated or uncultivated livingnmatter, wherein the biofunctional material substrate is optionally substantiallyninsoluble in the polymer substrate and/or a supercritical fluid, wherein thenprocess comprises contacting a mixture of the substrates or their precursorsnwith a supercritical fluid under supercritical conditions and conditions ofnreduced viscosity and physical blending to plasticise and swell the polymer andndistribute the biofunctional material substrate throughout the polymer, andnreleasing the fluid under subcritical conditions, wherein the substrates arenadapted to be isolated in form of a solid admixture comprising thenbiofunctional material substrate in substantially unchanged chemical form, andnoptionally in substantially unchanged physical form, composition obtainednthereby, polymer matrix embodiment thereof and the process for itsnpreparation. |