| abstract |
This invention provides compositions and methods for increasing cellular respiration of melanized catecholamine neurons, and methods for alleviating symptoms or stopping appearance and/or progression of symptoms of Parkinson's disease and related conditions, characterized by nigrostriatal degeneration, as well as drug-induced dyskinesias, tardive dyskinesia, Neuroleptic Malignant Syndrome, and negative symptoms of schizophrenia. An effective amount of a neuromelanin-binding composition having a quinoline ring in a suitable pharmaceutical carrier is administered to patient in need of such treatment. Preferably the composition comprises (-)-chloroquine diphosphate. Selected adjuvants are also provided as part of the compositions of this invention. |