| abstract |
The present invention relates to methods for the identification and characterization of polypeptides with ligand activity for the G protein coupled receptor (GPCR) 192. The invention encompasses the use of the ligands in combination with the receptor for the development of assays/kits for the identification of molecules that affect the ability of the ligand to interact with the receptor. In addition, the invention relates to molecules affecting the expression of the ligands (e.g., antisense DNA, ribozymes, antibodies) that may modulate the activity of the receptor. The invention also encompasses the use of the ligands and their derivatives, molecules affecting ligand expression, and compounds that modulate receptor activity for the treatment of disorders involving GPCR 192, such as those of the central nervous system, metabolic disorders (e.g., pancreatic disorders), gastrointestinal disorders, immune disorders, and cancer. |