| abstract |
The present invention relates to a compound having activity in a cell-basedntyrosinase assay, obtainable or obtained by (a) culturing Streptomycesnhygroscopicus subsp. hygroscopicus (DSMZ deposit number DSM 40578); (b)nseparating the medium containing the compound from the bacterial cells; (c) solidnphase extraction of said medium, thereby obtaining a crude extract; (d) performingngel filtration of said crude extract; (e) taking a gel filtration fraction exhibitingnactivity in said assay; (f) performing HPLC of said fraction exhibiting activity in saidnassay; and (g) taking one or more HPLC fractions exhibiting activity in said assay,nthereby obtaining said compound. The present invention also relates to methodsnof cosmetic treatment comprising the administration of a compound representednby the general formula (I)n nand to uses of said compound for the preparation of a cosmetic composition.nPreferably, said use is a use wherein the application of the cosmetic compositionnmodulates, or, more preferably, brings about the pigmentation of the body part tonwhich said cosmetic composition is applied to. The present invention also relatesnto methods for identifying modulators of melanogenesis. |