| abstract |
The present invention relates to compounds of the formulae I and Ia,n nwherein R 0 ; R 1 ; R 2 ; R3 ; R4; R22, Q; V, G and M have the meanings indicated in the claims. Thencompounds of the formulae I and Ia are valuable pharmacologically active compounds. Theynexhibit a strong antithrombotic effect and are suitable for the therapy and prophylaxis ofncardiovascular disorders like thromboembolic diseases or restenoses. They are reversibleninhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can inngeneral be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa isnpresent or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa isnintended. The invention furthermore relates to processes for the preparation of compounds ofnthe formulae I and Ia, their use, in particular as active ingredients in pharmaceuticals, andnpharmaceutical preparations comprising them. |