http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1562934-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 |
| filingDate | 2003-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a254f51b3eff69df1a1aaf50641ce4a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccdb06bf7baf144801b3348a71165b92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d050be5f18bbca01a300fc399424ef61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad769974ad796060df96ea345975ab7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d54abb4e1e02294ed255b5a86a655e63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_231ebc54f59964565f45cd3124bb3b58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ff53df595d7585b87fe377d68bdebff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_659c08c303e42858f25c95ef4ceaf39a |
| publicationDate | 2005-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1562934-A1 |
| titleOfInvention | Amino-heterocycles as vr-1 antagonists for treating pain |
| abstract | The present invention provides a compound of formula (I): wherein V represents NR<SUP>5</SUP>, O, S, SO or S(O)<SUB>2</SUB>; W and X each independently represent CH or N; Y represents N, CH or C-Ar<SUB>2</SUB>, with the proviso that at least one, but no more than two, of W, X and Y are N; Z represents CH or C-Ar<SUB>2</SUB>, with the proviso that when Y is N or CH then Z is C-Ar<SUB>2</SUB>, and with the further proviso that when Y is C-Ar<SUB>2 </SUB>then Z is CH; Ar<SUB>1 </SUB>represents a fused 9 or 10 membered heterobicyclic ring system containing one, two, three or four heteroatoms selected from nitrogen, oxygen and sulfur, wherein at least one of the rings in said ring system is aromatic; Ar<SUB>2 </SUB>represents an aromatic ring selected from phenyl, pyridyl, pyrimidinyl and pyridazinyl which is optionally fused and substituted; R<SUP>1 </SUP>represents halogen, hydroxy, oxo, C<SUB>1-6</SUB>alkyl, C<SUB>2-6</SUB>alkenyl, C<SUB>2-6</SUB>alkynyl, haloC<SUB>1-6</SUB>alkyl, hydroxyC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkoxy, haloC<SUB>1-6</SUB>alkoxy, hydroxyC<SUB>1-6</SUB>alkoxy, C<SUB>3-7</SUB>cycloalkyl, C<SUB>3-7</SUB>cycloalkoxy, C<SUB>3-5</SUB>cycloalkylC<SUB>1-4</SUB>alkyl, cyano, nitro, SR<SUP>6</SUP>, SOR<SUP>6</SUP>, SO<SUB>2</SUB>R<SUP>6</SUP>, COR<SUP>6</SUP>, NR<SUP>3</SUP>COR<SUP>6</SUP>, CONR<SUP>3</SUP>R<SUP>4</SUP>, NR<SUP>3</SUP>SO<SUB>2</SUB>R<SUP>6</SUP>, SO<SUB>2</SUB>NR<SUP>3</SUP>R<SUP>4</SUP>, -(CH<SUB>2</SUB>)<SUB>m</SUB>carboxy, esterified -(CH<SUB>2</SUB>)<SUB>m</SUB>carboxy or -(CH<SUB>2</SUB>)<SUB>m</SUB>NR<SUP>3</SUP>R<SUP>4</SUP>; R<SUP>2 </SUP>represents hydrogen, halogen, hydroxy, C<SUB>1-6</SUB>alkyl, haloC<SUB>1-6</SUB>alkyl, C<SUB>3-7</SUB>cycloalkyl, C<SUB>1-6</SUB>alkoxy, haloC<SUB>1-6</SUB>alkoxy, unsubstituted phenyl or phenyl substituted with one or two groups selected from halogen, C<SUB>1-6</SUB>alkyl, haloC<SUB>1-6</SUB>alkyl, C<SUB>3-7</SUB>cycloalkyl, C<SUB>1-6</SUB>alkoxy or haloC<SUB>1-6</SUB>alkoxy; R<SUP>3 </SUP>and R<SUP>4 </SUP>are each independently hydrogen, C<SUB>1-6</SUB>alkyl, C<SUB>2-6</SUB>alkenyl, C<SUB>2-6</SUB>alkynyl, C<SUB>3-7</SUB>cycloalkyl or fluoroC<SUB>1-6</SUB>alkyl; or R<SUP>3 </SUP>and R<SUP>4 </SUP>and the nitrogen atom to which they are attached together form a heteroaliphatic ring of 4 to 7 ring atoms, optionally substituted by one or two groups selected from hydroxy or C<SUB>1-4</SUB>alkoxy, which ring may optionally contain as one of the said ring atoms an oxygen or a sulfur atom, S(O), S(O)<SUB>2</SUB>, or NR<SUP>5</SUP>; R<SUP>5 </SUP>represents hydrogen, C<SUB>1-4</SUB>alkyl, hydroxyC<SUB>1-4</SUB>alkyl or C<SUB>1-4</SUB>alkoxyC<SUB>1-4</SUB>alkyl; R<SUP>6 </SUP>represents hydrogen, C<SUB>1-6</SUB>alkyl, fluoroC<SUB>1-6</SUB>alkyl, C<SUB>3-7</SUB>cycloalkyl, unsubstituted phenyl, or phenyl substituted with one or two groups selected from halogen, C<SUB>1-6</SUB>alkyl, haloC<SUB>1-6</SUB>alkyl, C<SUB>3-7</SUB>cycloalkyl, C<SUB>1-6</SUB>alkoxy or haloC<SUB>1-6</SUB>alkoxy; m is either zero or an integer from 1 to 4; n is either zero or an integer from 1 to 3; or a pharmaceutically acceptable salt, N-oxide or a prodrug thereof; a pharmaceutical composition comprising it; its use in methods of treatment; use of it for the manufacture of a medicament for treating VR-1 related conditions such as those in which pain and/or inflammation predominate; and methods of treatment using it. |
| priorityDate | 2002-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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