http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1562929-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adb0e564374fedf34b36103d36e6455a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-293 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-157 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-017 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-293 |
| filingDate | 2003-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44d4f48b84c83b63ee50b92b9398198d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd67e072583e12575c8c53743478ff33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3388f1eb08093db4089fc2e34eb6a833 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef3ac81f6118aa5b64b4aa8740ffe500 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_919ba4139ee7dc13b62378a42608619e |
| publicationDate | 2007-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1562929-B1 |
| titleOfInvention | Manufacture of tocopheryl acetate |
| abstract | A process for the manufacture of 3-phytyl-2,5,6-trimethylhydroquinone-1-acetate, and optionally therefrom tocopheryl acetate, comprises either C-alkylating 2,3,6-trimethylhydroquinone-1-acetate with isophytol or phytol in the presence of a sulphur(VI) containing catalyst of the formula R<SUP>1</SUP>SO<SUB>2</SUB>OH, wherein R<SUP>1 </SUP>signifies hydroxy, halogen, lower alkyl, halogenated lower alkyl or aryl, in an aprotic organic solvent, or O-alkylating 2,3,6-trimethylhydroquinone-1-acetate with a phytyl halide in a polar aprotic organic solvent in the presence of a base, and subjecting the so-obtained 4-O-phytyl-2,3,6-trimethylhydro-quinone-1-acetate to a rearrangement reaction, and in each case optionally submitting the so-obtained 3-phytyl-2,5,6-trimethylhydroquinone-1-acetate to a ring closure reaction to produce tocopheryl acetate. The invention also includes the novel compound 3-phytyl-2,5,6-trimethylhydroquinone-1-acetate and certain stereoisomers thereof, and also the further novel compound 4-hydroxy-2,3,6-trimethyl-5-[3-(4,8,12-trimethyltridecyl)-but-3-enyl]phenyl acetate which itself is one of several isomers of 3-phytyl-2,5,6-trimethylhydroquinone-1-acetate formed by isomerization under the influence of heating, e.g. during its distillation as part of the isolation and purification procedure following its manufacture as indicated above. (All-rac)-alpha-tocopherol, which may be derived from its acetate, is known to be the most active industrially important member of the vitamin E group. |
| priorityDate | 2002-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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