| abstract |
A purpose of the present invention is to provide TNF-αnproduction inhibitors being useful as therapeutic agents fornautoimmune diseases such as rheumatoid arthritis. Novelncompounds having the structure represented by the general formulan[1] or salts thereof according to the present invention have excellentnTNF-α production inhibitory activities,n n"A" is -(CR 5 R 6 )-, "B" is alkylene or alkenylene, R 1 is alkyl, etc;nR 2 is adamantylalkyl, adamantyloxyalkyl, adamantylaminoalkyl ornadamantylaminocarbonylalkyl; R 3 is a pyridine ring;R 5 and R 6 arenhydrogen, alkyl etc.;R 7 is hydrogen or alkyl; "X" is O or S; and "n"nis an integer of 1 to 5. |