abstract |
Base addition salts of an organoboronic acid inhibitor of thrombin having a neutral thrombin S1-bindingnmoiety are made by combining a solution of the organoboronic acid in a water-misciblenorganic solvent with an aqueous solution or suspension of a base, causing or allowing the acid andnthe base to react, and recovering the salt. An intermediate composition in the preparation of thensalts is a solution whose solvent is a water-miscible organic solvent and which contains speciesnselected from the organoboronic acid, and equilibrium forms of the organoboronic acid. |