| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8d329ebc42039eba20b21f1e2155e5d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b63e00734c7dae2e2dccd070bb2c62cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e9489a86218404bebc564842ff0f728 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-4291
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1024 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate |
2003-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff8a663258e047249e79b4a18c132b4c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d2adcd6ded37bc540a66d1966d2e80a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8999c844a6540f9dd3a0d1310faba8d |
| publicationDate |
2005-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1556508-A2 |
| titleOfInvention |
Antibodies and methods for generating genetically altered antibodies with high affinity |
| abstract |
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within immunoglobulins genes directed against an antigen of interest to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production. The invention also provides methods for increasing the affinity of monoclonal antibodies and monoclonal antibodies with increased affinity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9637556-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9260533-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8603950-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8685897-B2 |
| priorityDate |
2002-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |