| abstract |
Where Y, R 1 -R 8 and R 101 -R 108 are as definednin the specification. Compounds of formula (II) and methods of inhibiting thencytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF)ncomprising contacting MIF with a compound of formula (I) are provided. The inventionnalso relates to methods of treating diseases or conditions where MIF cytokinenor biological activity is implicated comprising administration of compoundsnof formula (I), either alone or as part of a combination therapy. |