abstract |
The present invention relates to mononucleoside phosphate compoundsthat have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that has been modified byattaching a degradation resistant substituent on the terminal phosphate of apolyphosphate mononucleotide. By attaching this degradation resistant substituent,the stability from degradation matches or exceeds those of certain dinucleotides. |