| abstract |
It is intended to disclose a modified glucose dehydrogenase characterized in that, in glucose dehydrogenase accompanied by pyrroloquinoline quinone as a coenzyme, one or more amino acid residues are substituted by other amino acid residues in the region of from the 186- to 206-residues in water-soluble PQQGDH originating in Acinetobacter caloaceticus or an equivalent region of another species. It is also intended to provide a gene encoding the modified glucose dehydrogenase as described above, a vector containing the gene, a transformant containing the gene, and a glucose assay kit and a glucose sensor containing the modified glucose dehydrogenase as described above. |