| abstract |
The present invention provides pyrazole derivativesnrepresented by the general formula:n nwherein R 1 represents H, an optionally substituted C 1-6 alkylngroup etc.; one of Q and T represents a group represented bynthe general formula:n nor a group represented by the general formula:n nwhile the other represents an optionally substituted C 1-6 alkylngroup etc.; R 2 represents H, a halogen atom, OH, an optionallynsubstituted C 1-6 alkyl group etc.; X represents a single bond,nO or S; Y represents a single bond, a C 1-6 alkylene group etc. ;nZ represents CO or SO 2 ; R 4 and R 5 represent H, an optionallynsubstituted C 1-6 alkyl group etc.; and R 3 , R 6 and R 7 represent nH, a halogen atom etc., pharmaceutically acceptable salts thereofnor prodrugs thereof, which exhibit an excellent inhibitorynactivity in human SGLT1 and are useful as agents for the preventionnor treatment of a disease associated with hyperglycemia suchnas diabetes, diabetic complications or obesity, andnpharmaceutical compositions comprising the same,npharmaceutical uses thereof, and intermediates for productionnthereof. |