abstract |
A novel polypeptide binding to SMG-1, a polynucleotidenencoding the same, and a system for screening a substancenwhich artificially modifies an mRNA surveillance mechanism,nare disclosed. The polypeptide has an activity of bindingnto SMG-1, an activity of being phosphorylated by SMG-1, andnan activity of modifying SMG-1 activities through thesenactivities. |