abstract |
The present invention relates to the clathrates of butylphtualide, which is D,L-mixed or levorotatory, with cyclodextrin or its derivatives, a process for their preparations and the use thereof. In the invention, the butylphthalide is included with cyclodextrin or its derivatives, prefered hydroxypropyl-β-cyclodextin, in order to improve the water-solubility of butylphthalide, develop clinical solid or liquid formulation and so that the curing effect of butylphthalide can exhibit better. The clathrate, in which the mole ratio of butylphthalide and cyclodextin or derivatives thereof is 1:1-10, can be used in preparing transfusion, injection, injectable powder, orally liquid, syrup, tablets, granules,dispersible tablets and others. |