| abstract |
An objective of the present invention is to provide compoundsnwhich have inhibitory activity against autophosphorylation ofnmacrophage colony-stimulating factor receptors. Thencompounds of the present invention are represented by formulan(I) and salt and solvate thereof:n nwherein X represents CH or N; Z represents O or S; R 1 , R 2 , andnR 3 represent H, optionally substituted alkoxy or the like; R 4 nrepresents H; R 5 , R 6 , R 7 , and R 8 represent H, halogen, alkyl,nalkoxy, trifluoromethyl or the like; R 9 and R 10 represent H, alkylnor the like; and any one of R 11 and R 12 represents H with thenother representing alkyl and R 13 represents an optionallynsubstituted carbocyclic or heterocyclic ring or the like, or R 11 nrepresents H and R 12 and R 13 combine together to form anbicyclic carbocyclic ring. |