| abstract |
This invention is related to compounds and use of N-Acyl-N'-benzylalkylendiamino derivatives of the following general formula I <CHEM> wherein A is a straight or branched C2-C8 alkyl chain; X is a methylene, oxygen, sulphur or a NR<7> group; R<1> is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R<2>, R<3> are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R<4>, R<5> are independently hydrogen or C1-C6 alkyl; R<6> is a hydrogen or a straight or branched C1-C8 alkyl or linked to R<5> can form a five to seven membered lactam; R<7> is hydrogen or C1-C6 alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role. |