abstract |
A novel polynucleotide sequence, which encodes a novel polypeptide belonging to the proton (H+)-gated cation channel subfamily, human Acid Sensing Ion Channel 2b (hAISC2b), is provided. Since hASIC2b and the other hASICs seem to constitute at least part of the native proton-gated cation channel of nociceptive neurons, cells coexpressing hASIC2b and the other hASICs are useful for a method of screening candidate compounds modulating the perception of acidity with regard to nociception. |