| abstract |
Disclosed is a topical method for providing adequate analgesic, anti-inflammatory, antimicrobial and tissue-regenerating activities for the hitherto most effective prophylaxis and treatment of aphtous ulcers and herpes simplex lesions and for the effective treatment of burns and other oral mucosal ulcers comprising topically administering to the affected tissue an effective amount of a composition comprised of one or more safe and efficacious polyvalent metal compounds such as magnesium sulfate, preferably with one or more safe and efficacious anti-inflammatory compounds, such as a novel ultra-low-strength hydrocortisone (acetate), that potentiate the activities of polyvalent metal compounds. Both the ionic and neutral moieties of the polyvalent metals are pharmacologically active; water-soluble and water-insoluble polyvalent metal compounds are both therapeutically effective. |