| abstract |
The present invention relates to new cheating agents to linknbiomolecules and carbonyl moieties for labeling withntechnetuim and rhenium. In particular the invention relatesnto bifunctional tridentate pyrazolyl-polyamines, pyrazolyl-aminothioethers,npyrazolyl-polythioethers, pyrazolyl-aminophosphinesnand pyrazolyl-thioetherphosphines whichnstabilize the moieties [M(CO) 3 ] + (M = Re, Tc, Mn) and bind tonbiomolecules which accumulate in diseased tissues. Theninvention relates to the chelators as such, to chelatorsncoupled to a biomolecule and to either of these complexednwith carbonyl. In addition the invention relates to a kit fornproviding radiolabeled biomolecules and to the use of suchnradiolabeled molecules in diagnosis and therapy. |