| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96ea792ca13ee47367f9dcf38eedda6b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-755
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70596 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-755
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2003-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9689ace0ef058100b425c7b75a1d565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3463b65d6cb091ba424af9a811e0d44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c463906f3d17d89c75ed0b454eacfa4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db187bcd67d1e3cdd347cfa491a9f6f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e4ae4627692e33122298fda565787eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7464f07a0929790bad39bcfa2befc6f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e35b9e74c0fdfe0c0d80b80be99236ce |
| publicationDate |
2005-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1527346-A1 |
| titleOfInvention |
Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha |
| abstract |
The invention relates to the adhesion of platelet GpIba to strand b3 of domain A1 of von Willebrand factor (vWF), said strand b3 comprising amino acid residues at amino acid position 560-566 and/or a functional part or equivalent thereof, said platelet GpIbalpha, said GpIbalpha region comprising an amino acid sequence corresponding to a beta-switch loop of platelet GpIbalpha, comprising amino acid residues at amino acid position 227-242 and/or a functional part or equivalent thereof. The invention provides a method to interfere with said adhesion of blood platelets to vWF comprising modulating said adhesion. The invention further provides proteinaceous compounds, antibodies, medicaments and pharmaceutical compositions to that end. The invention also provides means and methods to increase platelet adhesion by topical application of a compound increasing platelet adhesion. |
| priorityDate |
2002-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |