| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df874e3cf88adba3792dc9d5b5776180
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42f352cc5bd193c17ffff15bf60e16f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55588
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5068
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5152
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5154 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
1998-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f00614f917dc96eaee0af1a88126a425
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89858c9d9fd8246a281d03c430ad99dd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e57654f8e739cdbd399b7d2549d1721d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90c00a10ec798e3cd4a8e55bb82960a2 |
| publicationDate |
2009-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1523990-B1 |
| titleOfInvention |
Cellular vesicles denoted as 'exosomes', their preparation and use in the stimulation of an immune response |
| abstract |
Vesicle (A, designated texosome) derived from tumour cells (a) is separated from its natural environment and comprises a lipid bilayer surrounding a cytosolic fraction (CF) or (b) has diameter 60-90 nm and presents at its surface: (i) tumour-specific antigenic peptides associated with MHC (major histocompatibility complex) Class I and/or II molecules; and (ii) molecules (I) for co-stimulation of lymphocytes. Also new are: (1) antigen-presenting cells (APC) loaded with (A); (2) membrane vesicles (B) separated from their natural environment, secreted by the APC of (1); (3) membrane vesicles (C, designated dexosomes) derived from a dendritic cell (DC) and containing at least one each of MHC Class I and Class II molecules; (4) combination of texosomes and/or dexosomes with an immunostimulating adjuvant for use simultaneously, separately or staged in time; and (5) use of interleukin (IL)-10 and/or IL-12 for production of dexosomes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10240127-B2 |
| priorityDate |
1997-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |