| abstract |
A means and method for treating malaria, schistosomiasis, and cancer using andispiro 1,2,4-trioxolane is described. The 1,2,4-trioxolanes include anspiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on thenother side of the trioxolane group, whereby the spirocyclohexyl ring isnsubstituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, thencompounds of this invention are structurally simple, easy to synthesize, non-toxic, andnpotent against malarial parasites. |