| abstract |
An alkyl ether derivative represented by thenformula:n nwherein R 1 , R 2 , R 3 , R 4 , m and n are as defined in thenspecification, or salts thereof exhibitsnsynergistically improved anti-hypoxic activity whenncombined with a compound having an acetylcholinenesterase inhibitory activity. Therefore, thencombination according to the present invention isnuseful as a method for improving cerebral function.nFurther, a pharmaceutical composition containing thencompound relating to the combination according to thenpresent invention is useful for treatment andnprevention of dysfunction of cerebral acetylcholinenneurons in the sequelae of cerebrovascular dementia,nsenile dementia, Alzheimer's disease and ischemicncerebral lesion and in the cerebral apoplexy or thenmemory impairment caused by selective neuronal death. |