| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-70 |
| filingDate |
2003-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1342b1832313c29d4ac473d2b499fd95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_665c35db6e8108919e4bc357fc6606fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6854dd29b8dd8f7103ce834c4930225 |
| publicationDate |
2005-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1513956-A2 |
| titleOfInvention |
Assay to detect replication competent viruses |
| abstract |
A biological assay for detecting a non-selective replication competent virus (RCV) in a preparation of selectively-replicating virus. The method comprises -passaging the virus preparation at least once on cells that differentially amplify the selectively-replicating virus versus a replication competent virus and further analyzing the virus preparation, thereby detecting the presence of a replication competent virus. The further analysis of the virus preparation includes one or more of the following: detecting increased cytopathic effect; detecting increased virus production; detecting increased potency to kill normal cells; detecting an altered restriction digest pattern; detecting an altered viral genome sequence; detecting anticipated recombinants with PCR amplification; and detecting acute hepatotoxicity in an animal administered the virus preparation. In one embodiment, the assay detects replication competent adenoviruses in a preparation of an oncolytic adenovirus. |
| priorityDate |
2002-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |