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filingDate 2003-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d59f4b4bd3c3cf1646d8b9c034add148
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8801168d660dc8256cd3e112651e0aa5
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publicationDate 2005-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1513505-A1
titleOfInvention An improved modified release preparation
abstract A modified release preparation having one or more coated core elements. Each core element includes an active ingredient and has a modified release coating. A stablising coat is provided between each core element and its modified release coating so that, upon in vitro dissolution testing, the amount of active ingredient released at any time on a post-storage dissolution profile is within 40 percentage points of the amount of active ingredient released at any time on a pre-storage dissolution profile. The invention also provides a method of administering an active ingredient that, upon administration in an immediate release form, normally causes nausea and gastric irritation, the method including administering a modified release preparation of the invention.
priorityDate 2002-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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