| abstract |
The invention provides novel (2S)-2-ethylphenylpropanoic acidnderivatives that bind to the receptor as ligands of human peroxisomenproliferator-activated receptor (PPAR) α to activate and exhibitnlipid-lowering effect, inhibitory effect on the arteriosclerosis,nantiobesity effect, blood glucose-lowering effect, etc., theirnaddition salts, and their medicinal compositions. n (2S)-2-Ethylphenylpropanoic acid derivatives represented by angeneral formula (1)n n[wherein R1 denotes a halogen atom or trifluoromethyl group, R2ndenotes a hydrogen atom, halogen atom or trifluoromethyl group, and,nwhen R2 denotes a hydrogen atom, R3 denotes a halogen atom orntrifluoromethyl group and, when R2 denotes a halogen atom orntrifluoromethyl group, R3 denotes a hydrogen atom, halogen atom orntrifluoromethyl group], and their addition salts. |