| abstract |
The invention concerns a controlled release hydromorphone dosage form comprising a multiparticulatensystem substrate comprising an effective amount of hydromorphone salt, thensubstrate being coated with an aqueous dispersion of at least one hydrophobic polymer,nwhereby the coating provides controlled release and the release is further influenced by thenaddition of at least one release-modifying agent, whereby the dosage form comprises thencured, coated substrate and provides a therapeutic effect for at least 12 hours whennadministered to a patient. |