http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1500697-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6422dae6be0eabd1fc69a06dcf31379 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0693 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0645 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0697 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0786 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-09 |
| filingDate | 2004-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6186120d0400e0604d4bb88990fdf5d9 |
| publicationDate | 2005-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1500697-A2 |
| titleOfInvention | Bioartifical, primarily vascularized tissue for pharmaceutical tests, method for its production, test using said tissue and use of it in a bioreactor. |
| abstract | The invention relates to a bioartificial, primarynvascularized test tissue for pharmacological ornradiotherapeutic test procedure, a method fornProduction of such a fabric and a test methodnusing such a test tissue and anBioreactor for carrying out the process.n n n eine dezellularisierte, primär vaskularisierte, biologischenGewebematrix mit wenigstens einem Gefäßast, wobei die Gewebematrixnmit humanen Tumor- oder Leberzellen besiedelt ist.nBei der Herstellung wird vorteilhafterweise ein Nährstoffmedium,ninsbesondere autologes Blut, pulsierend zugeführt. According to the invention, the test fabric comprises: a decellularized, primarily vascularized, biological tissue matrix having at least one vascular branch, wherein the tissue matrix is populated with human tumor or liver cells. During production, a nutrient medium, in particular autologous blood, is advantageously supplied in a pulsating manner. n n n Bereitstellen des erfindungsgemäßen, bioartifiziellen,nprimär vaskularisierten Testgewebes, nZuführen des Pharmakons in einem Nährstoffmedium, das übernmindestens einen Gefäßast zugeführt wird, undnUntersuchen des Testgewebes, woraufhin vorzugsweisenin Abhängigkeit der Untersuchung durch Änderung der Pharmaka-Konzentrationnund/oder der Applikationsdauer dernPharmazufuhr und/oder einer strahlentherapeutischen Behandlungngezielt verändert werden:n Zellzyklus, Poliferation, Syntheserate, Stoffwechsel,nEntstehungsrate neuer Blutgefäße, Variationen im Expressionsmusternvon Adhäsionsmolekülen, Zell-Zell- und Zell-Matrix-Interaktionennauf RNA- und Proteinebene. n The test method according to the invention has at least the following steps: Providing the bioartificial primary vascularized test tissue of the invention, Supplying the drug in a nutrient medium, which is supplied via at least one vessel branch, and examining the test tissue, whereupon preferably depending on the examination by changing the pharmaceutical concentration and / or the application time of the pharmaceutical supply and / or a radiotherapy treatment are selectively changed: Cell cycle, poliferation, rate of synthesis, metabolism, formation of new blood vessels, variations in the expression pattern of adhesion molecules, cell-cell and cell-matrix interactions at the RNA and protein levels. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11617817-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11324858-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11266766-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11338065-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9226494-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010033820-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10004826-B2 |
| priorityDate | 2003-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.