| abstract |
The present invention provides a novel thiol derivativen[I] which has an excellent matrix metalloproteaseninhibiting activity and is useful as a pharmaceuticalncomposition, particularly a therapeutic agent ornprophylactic agent for osteoarthritis and rheumatoidnarthritis and a salt thereof, the thiol derivative being ancompound represented by the formula [I]:n n wherein ring A represents an optionally substitutednaromatic heterocyclic ring; n ring B represents an optionally substituted homocyclicnor heterocyclic ring; n R 1 represents a hydrogen atom, an optionallynsubstituted hydrocarbon group, an acyl group, an optionallynsubstituted heterocyclic group or SR 2 (wherein R 2 representsna hydrogen atom, an optionally substituted hydrocarbonngroup, an acyl group or an optionally substitutednheterocyclic group); n X represents an optionally substituted divalent C 1-3 naliphatic hydrocarbon group; n Y represents an optionally substituted hydrocarbonngroup, a halogen atom, a carboxy group, an acyl group, annoptionally substituted hydroxy group, an optionallynsubstituted amino group, SR 3 (wherein R 3 represents anhydrogen atom, an optionally substituted hydrocarbon group,nan acyl group or an optionally substituted heterocyclicngroup), an oxo group, a thioxo group, an optionallynsubstituted imino group, a nitro group or a cyano group;nand n q represents an integer of 0 to 5. |