| abstract |
The present invention relates to crystal forms of mammmalian OSC and the crystalnstructure information obtained from them, to methods of preparing such crystal forms,nand to their use for the identification and/or design of inhibitors of OSC activity. Anfurther subject matter of the invention are methods for the identification and/or designnof inhibitor compounds of OSC activity, the inhibitor compounds of OSC activitynidentified by these methods and their use in pharmaceutical compositions for thentreatment and/or prevention of diseases which are associated with OSC comprisingnhypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasiteninfections and gallstones, and/or treatment and/or prophylaxis of impaired glucosentolerance, diabetes, tumors and/or hyperproliferative disorders, preferably for thentreatment and/or prophylaxis of hypercholesterolemia and/or hyperlipemia. |