| abstract |
Thienyl-, furyl- and pyrrolyl-sulfonamides, pharmaceutically-acceptable saltsnof sulfonamides, formulations of salts and the sulfonamides, and methods of alteringnthe activity of the endothelin family of peptides using the formulations andnsulfonamides are provided. In particular, formulations of sodium salts of N-(isoxazolyl)thienylsulfonamides,nN-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolysulfonamidesnare provided. A process of preparing an alkali metalnsalt of a hydrophobic sulfonamide is provided. The process includes the step ofndissolving a free sulfonamide in an organic solvent in the presence of a saturatednalkali metal salt solution and recovering the formed sulfonamide salt from thenorganic plant. |