| abstract |
The present invention concerns methods and reagents useful in modulating G72 and/or D-amino acid oxidase (DAAO) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against G72 and/or D-amino acid oxidase (DAAO) gene expression and/or activity. The siNA molecules are useful in the treatment of schizophrenia and any other condition that responds to modulation of G72 and/or DAAO expression or activity. |