http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1493735-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2002-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4fdd4b695e761e5acd7b6141185a731 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47ed4d14b5df8584266f187895a446e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51560fac09f8674af6bc95c85e2f10a6 |
| publicationDate | 2005-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1493735-A1 |
| titleOfInvention | Pyrimidine derivatives useful as selective cox-2 inhibitors |
| abstract | The invention provides the compounds of formula (I) in which:R<sup>1</sup> is selected from the group consisting of H, C<sub>1-6</sub>alkyl, C<sub>1-2</sub>alkyl substituted by one to five fluorine atoms, C<sub>3-6</sub>alkenyl, C<sub>3-6</sub>alkynyl, C<sub>3-10</sub>cycloalkylC<sub>0-6</sub>alkyl, C<sub>4-12</sub>bridged cycloalkyl, A(CR<sup>4</sup>R<sup>5</sup>)<sub>n</sub> and B(CR<sup>4</sup>R<sup>5</sup>)<sub>n</sub>;R<sup>2</sup> is C<sub>1-2</sub>alkyl substituted by one to five fluorine atoms;R<sup>3</sup> is selected from the group consisting of C<sub>1-6</sub>alkyl, NH<sub>2</sub> and R<sup>7</sup>CONH;R<sup>4</sup> and R<sup>5</sup> are independently selected from H or C<sub>1-6</sub>alkyl;A is an unsubstituted 5- or 6-membered heteroaryl or an unsubstituted 6-membered aryl, or a 5- or 6-membered heteroaryl or a 6-membered aryl substituted by one or more R<sup>6</sup>;R<sup>6</sup> is selected from the group consisting of halogen, C<sub>1-6</sub>alkyl, C<sub>1-6</sub>alkyl substituted by one more fluorine atoms, C<sub>1-6</sub>alkoxy, C<sub>1-6</sub>alkoxy substituted by one or more F, NH<sub>2</sub>SO<sub>2</sub> and C<sub>1-6</sub>alkylSO<sub>2</sub>;B is selected from the group consisting of where defines the point of attachment of the ring;R<sup>7</sup> is selected from the group consisting of H, C<sub>1-6</sub>alkyl, C<sub>1-6</sub>alkoxy, C<sub>1-6</sub>alkylOC<sub>1-6</sub>alkyl, phenyl, HO<sub>2</sub>CC<sub>1-6</sub>alkyl, C<sub>1-6</sub>alkylOCOC<sub>1-6</sub>alkyl, C<sub>1-6</sub>alkylOCO, H<sub>2</sub>NC<sub>1-6</sub>alkyl, C<sub>1-6</sub>alkylOCONHC<sub>1-6</sub>alkyl and C<sub>1-6</sub>alkylCONHC<sub>1-6</sub>alkyl; andn is 0 to 4.Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a variety of conditions and diseases. |
| priorityDate | 2001-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 295.