| abstract |
The present invention relates to a conjugate of hydrophilicnpolymer-multicarboxyl oligopeptide and drug molecule of the following formula:n nwherein: P is a water soluble polymer; m is an integer of 2∼12; j is an integer of 1∼6;nR i is a group selected from H, C 1-12 alkyl, substituted aryl, aralkyl, heteroalkyl andnsubstituted alkyl; X and Z are linking groups; and TA is drug molecule. The conjugatenhas low toxicity and an ability to carry more than one drug molecule to improvensolubility, sustain and control drug release, and has a remarkably enhancing effectnespecially to antitumor drug such as paclitaxel and camptothecin etc. |