| abstract |
Compositions and methods for use in treating benign gynecological disorders, wherein anneffective amount of an antiprogestational agent [e.g., progesterone (progestin, progestogen,ngestagen) antagonist or progesterone synthesis inhibitor] administered over a first period ofntime is combined with an effective amount of a progestogen for a second period of time.nThe antiprogestational agent is selected from single agents or mixture thereof. The progestogennis selected from single agents or mixtures of natural or synthetic progestogens.nThe formulations are effective as contraceptive agents and for treatment of benign gynecologicalndisorders including uterine fibroids, premestrual syndrome, dysfunctional uterinenbleeding, polycystic ovarian syndrome and endometriosis. |