Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_46548e1e30b25078d7486f39400b3fe2 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2035-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5154 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-064 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0784 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
filingDate |
2003-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d867d70a10890260a847bfe4617b9cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a8ef744315bd93cd3ac8d98619077e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ec268abd486b364d3aefb9a9688461c |
publicationDate |
2004-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-1487970-A2 |
titleOfInvention |
Tolerogenic antigen-presenting cells |
abstract |
It has been found that dendritic cells can be prepared which cannot mature. These cells can provide signal (1) to T cells but cannot provide co-stimulatory signal (2). T cells which are stimulated by the permanently immature dendritic cells therefore anergise, so the dendritic cells are tolerogenic rather than immunogenic. The cells are generally CD40-ve, CD80-ve and CD86-ve, and remain so when stimulated by inflammatory mediators such as lipopolysaccharide. The cells can be prepared conveniently by the culturing adherent embryonic stem cells in the presence of GM-CSF. |
priorityDate |
2002-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |