abstract |
The present invention provides a method of treating hypertension, liver failure, loss of patency of ductus arteriosus, glaucoma or ocular hypertension in a patient, comprising administering to the patient a therapeutically effective amount of a selective EP<SUB>4 </SUB>receptor agonist of Formula I or a prodrug thereof, a pharmaceutically acceptable salt of the selective EP<SUB>4 </SUB>receptor agonist or prodrug or a stereoisomer or diastereomeric mixture of the EP<SUB>4 </SUB>receptor agonist, prodrug or salt, wherein the variables X, Z, Q, <img id="CUSTOM-CHARACTER-00001" he="2.79mm" wi="6.35mm" file="US07414071-20080819-P00001.TIF" alt="custom character" img-content="character" img-format="tif"/>, and R<SUP>2 </SUP>are as defined in the specification. |