http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1485352-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dfae81468523c4a7e635145a1bfe2359 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D497-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-96 |
| filingDate | 2003-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f8dcc69f9f0d64ac8f13904efd434b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a4b147ac50c366b872a5145542719a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03674dbd66591e8d9dfc049401e6580e |
| publicationDate | 2005-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1485352-B1 |
| titleOfInvention | Azaspiro compounds for the treatment of pain |
| abstract | New azaspiro compounds (I) useful as medicaments. Azaspiro compounds of formula (I) and their tautomers and salts useful as medicaments are new; [Image] X1, X2H; X1+X2S or NOH; R1H; R2H, OH, CHO, COOH, halo, SH, sulfonyl, amino, amido or R7Q1; R3H, OH, amino or R8Q2; Z : 4-to 10-membered C-bonded ring that contains 0-2 O or S atoms and is optionally substituted with OH, CHO, COOH, halo, SH, sulfonyl, amino, amido or R9Q3; R7-R9A, 3-6C cycloalkyl, 2-5C alkenyl, 2-5C alkynyl, OA, COA, COOA, SA, NHA, SOA, SO2A, A'NHA, A'SA or A'OA; A : 1-5C alkyl; A' : 1-5C alkylene; Q1-Q3H, OH, CHO, COOH, halo, SH, sulfonyl, amino or amido, but Q2 is not amino; R1+R2oxo or thioxo. Independent claims are also included for: (1) a pharmaceutical composition comprising (I) and an excipient; and (2) the use of an azaspiro compound of formula (II) for producing a medicament for treating pain. [Image] X3, X4H; X3+X4S or NOH; R4, R5H, OH, CHO, COOH, halo, SH, sulfonyl, amino, amido or R10Q4; R4+R5oxo or thioxo; R6H, OH, amino or R11Q5; Z24- to 10-membered C-bonded ring that contains 0-2 O or S atoms and is optionally substituted with OH, CHO, COOH, halo, SH, sulfonyl, amino, amido or R12Q6; R10-R12A, 3-6C cycloalkyl, 2-5C alkenyl, 2-5C alkynyl, OA, COA, COOA, SA, NHA, SOA, SO2A, A'NHA, A'SA or A'OA; Q4-Q6H, OH, CHO, COOH, halo, SH, sulfonyl, amino or amido. All other definitions are as above. ACTIVITY : Analgesic; Antiinflammatory. 2-Azaspiro[4,6]undecane-3-thione gave an 83% reduction in foot licking over controls in the Wheeler-Aceto formalin test after 20-25 minutes at an intraperitoneal dose of 32 mg/kg, compared with 64% for gabapentin lactam. MECHANISM OF ACTION : None given. |
| priorityDate | 2002-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.