| abstract |
This invention relates to compounds that inhibit farnesyl-protein transferase and rasnprotein farnesylation, thereby making them useful as anti-cancer agents. Thencompounds are also useful in the treatment of diseases, other than cancer,nassociated with signal transduction pathways operating through ras and thosenassociated with proteins other than ras that are also post-translationally modified bynthe enzyme farnesyl protein transferase. The compounds may also act as inhibitorsnof other prenyl transferases, and thus be effective in the treatment of diseasesnassociated with other prenyl modifications of proteins. |