| abstract |
A PKB (Akt) activator containing a compound represented by the formula (I) [wherein R1 and R2 each represents hydrogen, a hydrocarbon group, or a heterocyclic group or R1 and R2 form a ring in cooperation with the adjacent carbon atom; R3 represents hydrogen, a hydrocarbon group, or a heterocyclic group; W represents a group represented by the formula (II) (III) or (IV) (wherein ring A represents an optionally substituted benzene ring; ring B represents an optionally substituted 5- to 7-membered nitrogenous heterocycle; R4 represents either an aromatic-group-substituted aliphatic hydrocarbon group which may have other substituent(s) or an acyl containing an aromatic group; R5 represents hydrogen, C1-6 alkyl, or acyl; R4c represents an aromatic group, aliphatic hydrocarbon group, or acyl; and X represents oxygen or sulfur); Y represents oxygen, sulfur, or NH; and ring C represents an optionally substituted benzene ring], a salt of the compound, or a prodrug of either. Also provided is a use of the activator in or as a preventive/therapeutic agent for depressive psychoses, anxiety disorders, affective psychoses, or PTSD. |