| abstract |
The invention relates to a combination, comprising a selective inhibitor of COX-2, or a phamaceutically acceptable salt thereof, and an Alpha-2-delta ligand, or a pharmaceutically acceptable salt thereof, and valdecoxib. Examples of slective inhibitors of COX-2 include valdecoxib, rofecoxib, and celecoxib. Exampoes of Alpha-2 delta ligands include gabapentin, pregabalin (3S, 4S)-(1-Aminomethyl-3,4-dimethyl-cyclopentyl)-acetic acid, and 3-(1-aminomethyl-cyclohexymethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride. The combinations are useful for treating certain diseases inclduing cartilage damage, inflammation, pain, and arthritis. |