| abstract |
The invention concerns controlled release oxycodone dosage forms comprising a multiparticulatensystem substrate comprising an amount of an oxycodone salt, the substrate beingncoated with an aqueous dispersion of at least one hydrophobic polymer, whereby the coatingnprovides controlled release, the substrate including an additional dose of an oxycodone saltnincluded in either the controlled release coating or in an additional overcoating coated on thenouter surface of the controlled release coating, whereby the dosage forms, comprising thencured, coated substrate, comprise an effective amount of an oxycodone salt and provide antherapeutic effect for at least 12 hours when administered to a patient. |