| abstract |
The invention relates to substituted hydroxyindoles of the general formula 1 A process for their preparation, pharmaceutical compositions containing these compounds and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active substances for the treatment of diseases associated with an inhibition of phosphodiesterase 4 activity in immunocompetent cells (eg macrophages and lymphocytes ) are to be influenced by the compounds of the invention. |