abstract |
The invention relates to substituted hydroxyindoles of the general formula 1 , Process for their preparation, pharmaceutical preparations which contain these compounds and the pharmaceutical use of these compounds which are inhibitors of phosphodiesterase 4 as active substances for the treatment of diseases which inhibit phosphodiesterase 4 activity in immunocompetent cells (for example macrophages and lymphocytes ) are to be influenced by the compounds according to the invention. |