| abstract |
The invention concerns controlled release oxycodone dosage forms comprising a multiparticulatensystem substrate comprising an effective amount of oxycodone salt, the substratenbeing coated with an aqueous dispersion of at least one hydrophobic polymer, whereby thencoating provides controlled release and the release is further influenced by the addition of atnleast one release-modifying agent, whereby the dosage forms comprise the cured, coatednsubstrate and provide a therapeutic effect for at least 12 hours when administered to a patient. |