| abstract |
Heterocyclic compounds represented by the general formula (I)nand having elastase inhibiting activity; and intermediates for thensynthesis thereof: (I) wherein R 1 is a heterocyclic group represented bynthe general formula (II): (II) [wherein A represents the presence ornabsence of a benzene ring; X is oxygen, sulfur or NH; and Y is nitrogennor CH], and the heterocyclic group may be substituted with one to threensubstituents which may be the same or different and are selected fromnthe group consisting of lower alkyl, lower alkoxy, and phenyl which maynbe substituted with optionally halogenated lower alkyl, lower alkoxy ornhalogeno; and R 2 and R 3 are each hydrogen or hydroxyl, or R 2 and R 3 nmay be united to form an oxo group, with the proviso that both are notnhydrogen. |